This article explores the complex challenges associated with detecting and identifying radioactive hotspots in the nuclear industry using gamma cameras. Gamma cameras facilitate the localization of radioactive hotspots by overlaying a visualization of radioactivity onto a visible image. In the nuclear industry, gamma rays are observed in an energy range spanning from 59.5 keV (Am-241) to 1.3 MeV (Co-60). The motivation for this exploration stems from a specific challenge: characterizing hot-cells inaccessible to human operators. At the ORANO La Hague radioactive waste reprocessing plant, access to these restricted regions is possible through apertures with diameters ranging from 8 to 10 cm. In collaboration, the Nanopix-v1, characterized by its compact form as a coded mask gamma imaging system, with dimensions of 8 × 5.1 × 4.3 cm³ and a mass of 268 g, was developed through the synergistic efforts of CEA List and X-ray Imaging Europe (XIE) in partnership with ORANO. This article conducts a detailed examination of the laboratory and in situ performance of the Nanopix-v1, carried out within the challenging operational environment of the La Hague radioactive waste reprocessing plant. The focal point of the article is a comprehensive exploration of the technological components supporting the Nanopix-v1, along with an explanation of the coded mask imaging localization methodologies that underpinned the rigorous evaluation process. The performance of the gamma camera is evaluated through a series of carefully conducted trials, aimed at evaluating the angular resolution and minimum measurement time, including laboratory conditions, experimentation within a metrological Cs-137 irradiator, and practical implementation at the ORANO La Hague site.