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Communication Dans Un Congrès Année : 2023

Comparison of the biocatalytic performances of immobilized nitrilase in milli-scale reactors for continuous production of nicotinic acid

Résumé

Enzyme immobilization strategies are being actively investigated by the scientific community. In addition to the obvious interest of re-use of the biocatalyst, it is also essential for process intensification with integration of continuous operations [1]. Flow catalysis is indeed highly coveted by industrials to maximize the productivity but represent a major challenge. In this regard, the pharmaceutical industry has expressed its willingness to move from their traditional batch production to a continuous operating mode [2]. Promising technologies with high scaling potential due to their maturity are packed bed reactors (PBR) and wall immobilized enzyme reactors. Miniaturization at microscale for better mixing conditions have been the privileged option for wall immobilized enzyme reactors [3]. However, sizing up and numbering up should be combined to mitigated the complexity and cost of the heating and pumping apparatus at industrial scale [4]. With the reactor size increase, the geometry need to be optimized to maintain the mixing efficiency.
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Dates et versions

cea-04431030 , version 1 (01-02-2024)

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  • HAL Id : cea-04431030 , version 1

Citer

Maïté Michaud, Zoe Anxionnaz-Minvielle, Véronique de Berardinis, Guillaume Nonglaton, Anne Zaparucha, et al.. Comparison of the biocatalytic performances of immobilized nitrilase in milli-scale reactors for continuous production of nicotinic acid. BIOTRANS - 16th International Symposium on Biocatalysis & Biotransformations, Jun 2023, La Rochelle, France. ⟨cea-04431030⟩
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