Comparison of the biocatalytic performances of immobilized nitrilase in milli-scale reactors for continuous production of nicotinic acid
Résumé
Enzyme immobilization strategies are being actively investigated by the scientific community. In addition to the
obvious interest of re-use of the biocatalyst, it is also essential for process intensification with integration of
continuous operations [1]. Flow catalysis is indeed highly coveted by industrials to maximize the productivity but
represent a major challenge. In this regard, the pharmaceutical industry has expressed its willingness to move from
their traditional batch production to a continuous operating mode [2]. Promising technologies with high scaling
potential due to their maturity are packed bed reactors (PBR) and wall immobilized enzyme reactors. Miniaturization
at microscale for better mixing conditions have been the privileged option for wall immobilized enzyme reactors [3].
However, sizing up and numbering up should be combined to mitigated the complexity and cost of the heating and
pumping apparatus at industrial scale [4]. With the reactor size increase, the geometry need to be optimized to
maintain the mixing efficiency.
Domaines
Génie des procédésOrigine | Fichiers éditeurs autorisés sur une archive ouverte |
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