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Poster De Conférence Année : 2021

Influence of bne properties on transcranial acoustic propagation using ray tracing numerical simulations

Résumé

Objective For transcranial focused ultrasound therapy, acoustic energy is focused through the skull using a multi-element transducer. Using a ray-tracing numerical simulation method, a parametric study was conducted to examine the sensitivity of transcranial focalization quality to variations in the skull's acoustic properties, as well as to the effects of shear mode conversion and acoustic resonance. Methods The parametric study was performed using a ray-tracing method with a model of the human skull and acoustic source based on the ExAblate Neuro 650kHz (Insightec) clinical system. The skull properties, including density, acoustic velocity, and degree of heterogeneity were varied, while focalization quality was quantified using the focal amplitude and spatial position. The use of a ray-tracing model allowed for the contributions of shear mode conversion and acoustic resonance in both homogeneous and multi-layer models of the skull to be examined directly. Results The results of this study quantified the sensitivity of the intracranial acoustic field to variations of skull density, acoustic velocity, and degree of heterogeneity. These findings illustrate how uncertainties in acoustic properties and increased heterogeneity can have deleterious effects on transcranial focusing. Simulations indicate that shear mode conversion had an appreciable effect on focalization quality in both homogeneous and multi-layer models of the skull, while the contributions from acoustic resonance remained negligible. Conclusion This study quantified the sensitivity of transcranial focalization quality to uncertainties in acoustic properties of the human skull, and demonstrate the importance of considering skull heterogeneity and shear mode conversion in ray-tracing models of transcranial acoustic propagation.
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Dates et versions

cea-04418213 , version 1 (25-01-2024)

Identifiants

  • HAL Id : cea-04418213 , version 1

Citer

Andrew Drainville, David Moore, John Snell, Sylvain Chatillon, Cyril Lafon, et al.. Influence of bne properties on transcranial acoustic propagation using ray tracing numerical simulations. ISTU 2021 - International Symposium for Therapeutic Ultrasound, Jun 2021, Gyeonju, South Korea. , 2021. ⟨cea-04418213⟩
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