Syn-cryptophanes: macrocyclic compounds with optimized characteristics for the design of 129 Xe NMR-based biosensors
Abstract
A new water-soluble xenon host system with great promise for the 129 Xe NMR-based biosensing approach is presented: the syn-cryptophane-222-hexacarboxylate. It compares favorably with its already known anti diastereomer, on the one hand, and with cucurbit[6]uril, on the other hand, in particular in terms of xenon binding constant and xenon in-out exchange, a key parameter for the efficiency of the most sensitive HyperCEST method.
Domains
Material chemistry| Origin | Publisher files allowed on an open archive |
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