Iridium complexes inhibit tumor necrosis factor-α by utilizing light and mixed ligands

We report herein a large study of the inhibition of tumor necrosis factor-α with 51 iridium(III) complexes, thus highlighting the influence of the nature of the ligands around the metal, their synergic effect and the role of the light.

Keywords

WATER Light Tumour necrosis factor Platinum Group Compounds CATALYSIS COPPER METAL-COMPLEXES ANTICANCER AGENTS Cancer treatment ORGANOMETALLIC COMPOUNDS Cancer Therapy Tumours RUTHENIUM COMPLEXES Iridium complexes Inhibition TNF-alpha

Domains

Organic chemistry Catalysis Cancer

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https://cea.hal.science/cea-01847044

Submitted on : Monday, July 23, 2018-10:53:29 AM

Last modification on : Tuesday, December 3, 2024-1:14:02 PM

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cea-01847044 , version 1 (23-07-2018)

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HAL Id : cea-01847044 , version 1
DOI : 10.1016/j.jorganchem.2016.02.001

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Elodie Sauvageot, Pierre Lafite, Eric Duverger, Ronan Marion, Matthieu Hamel, et al.. Iridium complexes inhibit tumor necrosis factor-α by utilizing light and mixed ligands. Journal of Organometallic Chemistry, 2016, 808, pp.122-127. ⟨10.1016/j.jorganchem.2016.02.001⟩. ⟨cea-01847044⟩

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