Iridium complexes inhibit tumor necrosis factor-α by utilizing light and mixed ligands

We report herein a large study of the inhibition of tumor necrosis factor-α with 51 iridium(III) complexes, thus highlighting the influence of the nature of the ligands around the metal, their synergic effect and the role of the light.

Mots clés

WATER Light Tumour necrosis factor Platinum Group Compounds CATALYSIS COPPER METAL-COMPLEXES ANTICANCER AGENTS Cancer treatment ORGANOMETALLIC COMPOUNDS Cancer Therapy Tumours RUTHENIUM COMPLEXES Iridium complexes Inhibition TNF-alpha

Domaines

Chimie organique Catalyse Cancer

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https://cea.hal.science/cea-01847044

Soumis le : lundi 23 juillet 2018-10:53:29

Dernière modification le : mardi 3 décembre 2024-13:14:02

Dates et versions

cea-01847044 , version 1 (23-07-2018)

Identifiants

HAL Id : cea-01847044 , version 1
DOI : 10.1016/j.jorganchem.2016.02.001

Citer

Elodie Sauvageot, Pierre Lafite, Eric Duverger, Ronan Marion, Matthieu Hamel, et al.. Iridium complexes inhibit tumor necrosis factor-α by utilizing light and mixed ligands. Journal of Organometallic Chemistry, 2016, 808, pp.122-127. ⟨10.1016/j.jorganchem.2016.02.001⟩. ⟨cea-01847044⟩

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