Catalytic methoxylation of aryl halides using $^{13}$C- and $^{14}$C-labeled CO$_2$ - CEA - Commissariat à l’énergie atomique et aux énergies alternatives Access content directly
Journal Articles Chemical Communications Year : 2022

Catalytic methoxylation of aryl halides using $^{13}$C- and $^{14}$C-labeled CO$_2$

Abstract

The functionalization of carbon dioxide (CO2) into high-value building blocks is a relevant topic in carbon isotope labeling, where CO2 is the primary carbon source. A catalytic methoxylation of aryl halides directly from 13C and 14C CO2 is reported. Relying on the intermediacy of the methoxyborane BBN-OCH3, as new secondary nucleophilic labeled source, this strategy allowed labeling of a series of substrates, including challenging pharmaceuticals containing tertiary alkyl amine substituents.
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cea-03809925 , version 1 (11-10-2022)

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Attribution - NonCommercial

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Alexia Ohleier, Antoine Sallustrau, Bouchaib Mouhsine, Fabien Caillé, Davide Audisio, et al.. Catalytic methoxylation of aryl halides using $^{13}$C- and $^{14}$C-labeled CO$_2$. Chemical Communications, In press, 58, pp.12831-12834. ⟨10.1039/D2CC03746G⟩. ⟨cea-03809925⟩
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