Formulation of stimulable multiple emulsions by microfluidics
Abstract
Multiple emulsions, in particular water-in-oil-in-water (w/o/w) emulsions, are promising systems for encapsulation and controIled delivery of drugs. We developed a new emulsifier, a poly(dimethylsiloxane)-b-poly(dimethylaminoethylmethacrylate) (PDMS-b-PDMAEMA) amphiphilic copolymer, capable of stabilizing multiple emulsions in one mixing step over long times. This polymer is stimuli responsive, aIlowing the formation of direct, inverse and w/o/w emulsions depending on the pH and ionic strength. It is then possible to consider the controIled release of a compound encapsulated in the inner water droplets.
However it is highly desirable to both form monodisperse emulsions for reaching a reliable control of the delivery and differentiate the inner water phases carrying the cargo from the external water phase for avoiding tediol}s washing steps. For aIl these reasons microfluidics was considered as a promising tool and is shown here to provide first promising results.
Domains
Material chemistry
Origin : Files produced by the author(s)
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