Iron-Catalyzed Aryl-Aryl Cross-Coupling Reaction: Homo-versus Hetero-Coupling Reactions
Résumé
An in-depth mechanistic study was undertaken to explain the competition between the homo-and heterocoupling reactions in the case of iron-catalyzed aryl-aryl cross-couplings in the presence of C$_6$F$_5$Cl as an organic sacrificial oxidant. The formation of the homocoupling product is explained by a crucial iron-to-magnesium transmetallation of a C$_6$F$_{5─}$ anion arising from the bielectronic reduction of C6F5Cl. This mechanism is discussed and supported by experimental results, including $^1$H paramagnetic NMR and $^{57}$Fe-Mössbauer spectroscopies. These results enlighten the mechanistic features of iron-catalyzed Grignard oxidative homocoupling, and can provide guidance in the choice of suitable sacrificial oxidants for such systems.
Domaines
MatériauxOrigine | Fichiers produits par l'(les) auteur(s) |
---|
Loading...