Chemical reactions can have a significant impact on the overall rate of mass transfer in fluid–fluid applications (such as gas absorption in a liquid or liquid–liquid extraction). However, as for non reacting systems, the rate at which a solute is exchanged between the two fluids is difficult to predict accurately. Yet from a theoretical point of view, most studies address uniform diffusion transport or creeping flow, i.e. conditions enabling the derivation of analytical or simple numerical solutions of the solute transport equation, therefore neglecting the effect of convection in the case of coupled mass transfer problems. On the other hand, experimental investigations available in the literature provided correlations corresponding to flow conditions, shape and contamination of the interface which are extremely difficult to control precisely. Direct numerical simulation (DNS) is therefore a powerful tool to investigate the coupling of hydrodynamics with transfer and reaction. It was recently applied to model the internal and external resistances (or Sherwood numbers, and) prevailing during the transfer of a non reacting solute, in the general case of conjugate mass transfer from a moving spherical droplet (Godé et al., 2023; 2024). This study is complemented by considering a first order reaction that consumes the transferred solute in the continuous phase. The results indicate that the double film model, based on these last correlations for and , with corrected by an enhancement factor allows obtaining accurate predictions of the overall mass transfer coefficient in the case of a reactive conjugate problem, thus extending the work of Juncu (2002) to flows at moderate or even high , as long as the droplet remains spherical and the flow axisymmetric.