Improved electro-destruction of bacterial biofilms by coating conductive surfaces with polymers - CEA - Commissariat à l’énergie atomique et aux énergies alternatives
Article Dans Une Revue European Polymer Journal Année : 2024

Improved electro-destruction of bacterial biofilms by coating conductive surfaces with polymers

Résumé

The formation of biofilm involves cell aggregation and adherence, enveloped by a self-produced extracellular matrix. In the medical domain, biofilm-associated infections pose significant challenges, especially concerning implants. This investigation focuses on enhancing electromediated bacterial biofilm eradication through polymer coatings on the anode. These coatings catalyze reactive oxygen species (ROS) generation or convert hydrophobic coatings to bactericidal hydrophilic polycations, detaching the biofilms that are predominantly polyanionic. The first approach employs a metallized polytetrathienylporphyrin layer with ROS catalytic capability, while the second involves an insoluble hydrophobic polyamide, which, upon oxidation, transforms into a bactericidal hydrolytically degradable polycation. Both approaches show promising efficacy in augmenting electromediated Staphylococcus aureus biofilm destruction.

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Chimie
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Dates et versions

cea-04501255 , version 1 (12-03-2024)

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Citer

Stephane Hoang, Hanna Zhukouskaya, Iryna Ivanko, Jan Svoboda, Michaela Hympánová, et al.. Improved electro-destruction of bacterial biofilms by coating conductive surfaces with polymers. European Polymer Journal, 2024, 209, pp.112910. ⟨10.1016/j.eurpolymj.2024.112910⟩. ⟨cea-04501255⟩
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