Tungsten (VI) based “molecular puzzle” photoluminescent nanoparticles easily covered with biocompatible natural polysaccharides via direct chelation - CEA - Commissariat à l’énergie atomique et aux énergies alternatives Accéder directement au contenu
Article Dans Une Revue Journal of Colloid and Interface Science Année : 2018

Tungsten (VI) based “molecular puzzle” photoluminescent nanoparticles easily covered with biocompatible natural polysaccharides via direct chelation

Éric Doris

Résumé

Multimodal probes, which can be simultaneously visualized by multiple imaging modalities, enable the cellular uptake, intracellular fate, biodistribution and elimination to be tracked in organisms. In this study, we report the synthesis of crystalline WO3 and CaWO4 doped with Eu3+ or Tb3+ nanoparticles (size range of 10–160 nm) coated with polysaccharides, and these nanoparticles constitute a versatile easy-to-construct modular toolbox for multimodal imaging. The particles adsorb significant amounts of polysaccharides from the solution, providing biocompatibility and may serve as a platform for labeling. For WO3, the sorption is reversible. However, on CaWO4, stable coating is formed. CaWO4/Tb3+ coated with chemisorbed dextrin, mannan, guar gum and sodium alginate successfully underwent endocytosis with HepG2 cells and was visualized using confocal microscopy.

Domaines

Chimie
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Dates et versions

cea-04492470 , version 1 (06-03-2024)

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Volodymyr Lobaz, Martin Hladik, Miloš Steinhart, Aleksandra Paruzel, Peter Černoch, et al.. Tungsten (VI) based “molecular puzzle” photoluminescent nanoparticles easily covered with biocompatible natural polysaccharides via direct chelation. Journal of Colloid and Interface Science, 2018, 512, pp.308-317. ⟨10.1016/j.jcis.2017.10.056⟩. ⟨cea-04492470⟩
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