Combination of Aryl Diselenides/Hydrogen Peroxide and Carbon‐Nanotube/Rhodium Nanohybrids for Naphthol Oxidation: An Efficient Route towards Trypanocidal Quinones
Résumé
Abstract This work reports a combination of aryl diselenides/hydrogen peroxide and carbon‐nanotube (CNT)/rhodium nanohybrids (RhCNT) for naphthol oxidation towards the synthesis of 1,4‐naphthoquinones and evaluation of their relevant trypanocidal activity. Under a combination of (PhSe) 2 /H 2 O 2 in the presence of O 2 in i PrOH/hexane, several benzenoid (A‐ring)‐substituted quinones were prepared in moderate to high yields. We also studied the contribution of RhCNT as co‐catalyst in this process and, in some cases, yields were improved. This method provides an efficient and versatile alternative for preparing A‐ring‐modified naphthoquinonoid compounds with relevant biological profile.