Scalable total synthesis, IP3R inhibitory activity of desmethylxestospongin B, and effect on mitochondrial function and cancer cell survival - CEA - Commissariat à l’énergie atomique et aux énergies alternatives Accéder directement au contenu
Article Dans Une Revue Angewandte Chemie International Edition Année : 2021

Scalable total synthesis, IP3R inhibitory activity of desmethylxestospongin B, and effect on mitochondrial function and cancer cell survival

Résumé

The scalable synthesis of the oxaquinolizidine marine natural product desmethylxestospongin B is based on the early application of Ireland–Claisen rearrangement, macrolactamization, and a late‐stage installation of the oxaquinolizidine units by lactam reduction. The synthesis serves as the source of material to investigate calcium signaling and its effect on mitochondrial metabolism in various cell types, including cancer cells.
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Dates et versions

cea-04460323 , version 1 (15-02-2024)

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Maša Podunavac, Artur Mailyan, Jeffrey Jackson, Alenka Lovy, Paula Farias, et al.. Scalable total synthesis, IP3R inhibitory activity of desmethylxestospongin B, and effect on mitochondrial function and cancer cell survival. Angewandte Chemie International Edition, 2021, 60 (20), pp.11278-11282. ⟨10.1002/anie.202102259⟩. ⟨cea-04460323⟩
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