DNA methylation-based profiling of horse archaeological remains for age-at-death and castration - CEA - Commissariat à l’énergie atomique et aux énergies alternatives Accéder directement au contenu
Article Dans Une Revue iScience Année : 2023

DNA methylation-based profiling of horse archaeological remains for age-at-death and castration

Patrick Wincker

Résumé

Age profiling of archaeological bone assemblages can inform on past animal management practices, but is limited by the fragmentary nature of the fossil record and the lack of universal skeletal markers for age. DNA methylation clocks offer new, albeit challenging, alternatives for estimating the age-at-death of ancient individuals. Here, we take advantage of the availability of a DNA methylation clock based on 31,836 CpG sites and dental age markers in horses to assess age predictions in 84 ancient remains. We evaluate our approach using whole-genome sequencing data and develop a capture assay providing reliable estimates for only a fraction of the cost. We also leverage DNA methylation patterns to assess castration practice in the past. Our work opens for a deeper characterization of past husbandry and ritual practices and holds the potential to reveal age mortality profiles in ancient societies, once extended to human remains.
Fichier principal
Vignette du fichier
1-s2.0-S2589004223002213-main.pdf (10.24 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

cea-04286440 , version 1 (15-11-2023)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Xuexue Liu, Andaine Seguin- Orlando, Lorelei Chauvey, Gaëtan Tressières, Laure Tonasso-Calvie, et al.. DNA methylation-based profiling of horse archaeological remains for age-at-death and castration. iScience, 2023, 26 (3), pp.106144. ⟨10.1016/j.isci.2023.106144⟩. ⟨cea-04286440⟩
52 Consultations
21 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More