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Article Dans Une Revue Molecular Biology and Evolution Année : 2022

Giant viruses encode actin-related proteins

Résumé

The emergence of the eukaryotic cytoskeleton is a critical yet puzzling step of eukaryogenesis. Actin and actin-related proteins (ARPs) are ubiquitous components of this cytoskeleton. The gene repertoire of the Last Eukaryotic Common Ancestor (LECA) would have therefore harbored both actin and various ARPs. Here, we report the presence and expression of actin-related genes in viral genomes (viractins) of some Imitervirales, a viral order encompassing the giant Mimiviridae. Phylogenetic analyses suggest an early recruitment of an actin-related gene by viruses from ancient protoeukaryotic hosts before the emergence of modern eukaryotes, possibly followed by a back transfer that gave rise to eukaryotic actins. This supports a coevolutionary scenario between pre-LECA lineages and their viruses, which could have contributed to the emergence of the modern eukaryotic cytoskeleton.
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Origine : Publication financée par une institution
Licence : CC BY NC - Paternité - Pas d'utilisation commerciale

Dates et versions

cea-04281384 , version 1 (12-11-2023)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

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Violette da Cunha, Morgan Gaia, Hiroyuki Ogata, Olivier Jaillon, Tom O Delmont, et al.. Giant viruses encode actin-related proteins. Molecular Biology and Evolution, 2022, 39 (2), pp.msac022. ⟨10.1093/molbev/msac022⟩. ⟨cea-04281384⟩
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