Disease mechanisms of multiple system atrophy: What a parallel between the form of pasta and the alpha-synuclein assemblies involved in MSA and PD tells us - CEA - Commissariat à l’énergie atomique et aux énergies alternatives Access content directly
Journal Articles The Cerebellum Year : 2022

Disease mechanisms of multiple system atrophy: What a parallel between the form of pasta and the alpha-synuclein assemblies involved in MSA and PD tells us

Abstract

Intracellular deposits rich in aggregated alpha-synuclein that appear within the central nervous system are intimately associated to Parkinson's disease and multiple system atrophy. While it is understandable that the aggregation of proteins, which share no primary structure identity, such as alpha-synuclein and tau protein, leads to different diseases, that of a given protein yielding distinct pathologies is counterintuitive. This short review relates molecular and mechanistic processes to the observed pathological diversity associated to alpha-synuclein aggregation.
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cea-03827567 , version 1 (24-10-2022)

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Ronald Melki. Disease mechanisms of multiple system atrophy: What a parallel between the form of pasta and the alpha-synuclein assemblies involved in MSA and PD tells us. The Cerebellum, 2022, 2022, ⟨10.1007/s12311-022-01417-0⟩. ⟨cea-03827567⟩
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