Alkyl formates as transfer hydroalkylation reagents and their use in the conversion of imines to alkylamines - CEA - Commissariat à l’énergie atomique et aux énergies alternatives Access content directly
Journal Articles Angewandte Chemie International Edition Year : 2022

Alkyl formates as transfer hydroalkylation reagents and their use in the conversion of imines to alkylamines

Abstract

Easily accessible via a simple esterification of alcohols with formic acid, alkyl formates are used as a novel class of transfer hydroalkylation reagents, CO2 acting as a traceless linker. As a proof-of-concept, their reactivity in the transfer hydroalkylation of imines is investigated, using a ruthenium-based catalyst and LiI as promoter to cleave the C−O σ–bond of the formate scaffold. Providing tertiary amines, the reaction displays a reverse and complementary regioselectivity compared to previously reported transfer hydroalkylation strategies.
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cea-03712544 , version 1 (04-07-2022)

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Étienne Crochet, Lucile Anthore-Dalion, Thibault Cantat. Alkyl formates as transfer hydroalkylation reagents and their use in the conversion of imines to alkylamines. Angewandte Chemie International Edition, 2022, 62 (1), pp.e2022140. ⟨10.1002/anie.202214069⟩. ⟨cea-03712544⟩
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