Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation
Abstract
This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc) 2) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain.
Domains
Life Sciences [q-bio]
Origin : Files produced by the author(s)
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