Regeneration of fat cells from myofibroblasts during wound healing
Maksim Plikus
(1, 2)
,
Christian Guerrero-Juarez
(2)
,
Mayumi Ito
(3)
,
Yun Rose Li
(1)
,
Priya Dedhia
(4)
,
Ying Zheng
(1)
,
Mengle Shao
(5)
,
Denise L. Gay
(1, 6)
,
Raül Ramos
(2)
,
Tsai-Ching Hsi
(2)
,
Ji Won Oh
(2)
,
Xiaojie Wang
(2)
,
Amanda Ramirez
(2)
,
Sara Konopelski
(2)
,
Arijh Elzein
(2)
,
Anne Wang
(1)
,
Rarinthip June Supapannachart
(1)
,
Hye-Lim Lee
(2)
,
Chae Ho Lim
(3)
,
Arben Nace
(1)
,
Amy Guo
(1)
,
Elsa Treffeisen
(1)
,
Thomas Andl
(7)
,
Ricardo N. Ramirez
(2)
,
Rabi Murad
(2)
,
Stefan Offermanns
(8)
,
Daniel Metzger
(9)
,
Pierre Chambon
(9)
,
Alan Widgerow
(10)
,
Tai-Lan Tuan
(11)
,
Ali Mortazavi
(2)
,
Rana Gupta
(12)
,
Bruce Hamilton
(13)
,
Sarah Millar
(1)
,
Patrick Seale
(14)
,
Warren Pear
(4)
,
Mitchell A. Lazar
(15, 1)
,
George Cotsarelis
(1)
1
Perelman School of Medicine
2 Center for Complex Biological Systems
3 NYU - New York University School of Medicine
4 Abramson Family Cancer Research Institute
5 University of Texas Southwestern Medical Center
6 SCSR (U_967) - Stabilité génétique, Cellules Souches et Radiations
7 UCF - University of Central Florida [Orlando]
8 MPI-HLR - Max Planck Institute for Heart and Lung Research
9 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
10 Department of Biology & Center for Tissue Regeneration & Engineering
11 Keck School of Medicine [Los Angeles]
12 The University of Texas Southwestern Medical Center
13 Moores Cancer Center - Moores Cancer Center [UC San Diego Health]
14 Dana-Farber Cancer Institute and the Department of Cell Biology
15 Division of Endocrinology, Diabetes and Metabolism
2 Center for Complex Biological Systems
3 NYU - New York University School of Medicine
4 Abramson Family Cancer Research Institute
5 University of Texas Southwestern Medical Center
6 SCSR (U_967) - Stabilité génétique, Cellules Souches et Radiations
7 UCF - University of Central Florida [Orlando]
8 MPI-HLR - Max Planck Institute for Heart and Lung Research
9 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
10 Department of Biology & Center for Tissue Regeneration & Engineering
11 Keck School of Medicine [Los Angeles]
12 The University of Texas Southwestern Medical Center
13 Moores Cancer Center - Moores Cancer Center [UC San Diego Health]
14 Dana-Farber Cancer Institute and the Department of Cell Biology
15 Division of Endocrinology, Diabetes and Metabolism
Maksim Plikus
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- Fonction : Auteur correspondant
- PersonId : 1037483
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Daniel Metzger
- Fonction : Auteur
- PersonId : 180398
- IdHAL : daniel-metzger
- ORCID : 0000-0002-5555-046X
- IdRef : 086804901
Résumé
Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling and then activation of adipocyte transcription factors expressed during development. Overexpression of the BMP antagonist Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation. Adipocytes formed from human keloid fibroblasts either when treated with BMP or when placed with human hair follicles in vitro. Thus, we identify the myofibroblast as a plastic cell type that may be manipulated to treat scars in humans.