Late-stage isotopic carbon labeling of pharmaceutically relevant cyclic ureas directly from CO2 - CEA - Commissariat à l’énergie atomique et aux énergies alternatives Access content directly
Journal Articles Angewandte Chemie International Edition Year : 2018

Late-stage isotopic carbon labeling of pharmaceutically relevant cyclic ureas directly from CO2

Abstract

A robust, click chemistry inspired procedure for radiolabeling of cyclic ureas was developed. This protocol, suitable for all carbon isotopes (11C, 13C, 14C), is based on the direct functionalization of carbon dioxide: the universal building block for carbon radiolabeling. The strategy is operationally simple, reproducible in different radiochemistry centers, exhibits a remarkably wide substrate scope with short reaction times, and demonstrates superior reactivity compared to previously reported systems. With this procedure, a variety of pharmaceuticals and an unprotected peptide were labeled with high radiochemical efficiency.
Fichier principal
Vignette du fichier
Manuscript accepted version (1).pdf (847.59 Ko) Télécharger le fichier
Origin Files produced by the author(s)
Loading...

Dates and versions

cea-01818428 , version 1 (06-08-2018)

Identifiers

Cite

Antonio del Vecchio, Fabien Caillé, Arnaud Chevalier, Olivier Loreau, Kaisa Horkka, et al.. Late-stage isotopic carbon labeling of pharmaceutically relevant cyclic ureas directly from CO2. Angewandte Chemie International Edition, 2018, ⟨10.1002/anie.201804838⟩. ⟨cea-01818428⟩
204 View
151 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More