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authFullName_s : Nathalie Cartier

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology

Sophie Ayciriex , Marie-Anne Burlot , Jérome Braudeau , Kristin Michaelsen-Preusse , Brigitte Potier , et al.
Human Molecular Genetics, 2015, 24 (21), pp.5965 - 5976. ⟨10.1093/hmg/ddv268⟩
Journal articles hal-01779042v1
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Complete Correction of Brain and Spinal Cord Pathology in Metachromatic Leukodystrophy Mice

Emilie Audouard , Valentin Oger , Béatrix Meha , Nathalie Cartier , Caroline Sevin , et al.
Frontiers in Molecular Neuroscience, 2021, 14, ⟨10.3389/fnmol.2021.677895⟩
Journal articles hal-03254121v1
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The challenge of gene therapy for neurological diseases: strategies and tools to achieve efficient delivery to the central nervous system

Timothée de Saint Denis , Françoise Piguet , Emilie Audouard , Kevin Beccaria , Arthur André , et al.
Human Gene Therapy, 2021, 32 (7-8), pp.349-374. ⟨10.1089/hum.2020.105⟩
Journal articles hal-03265982v1

βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer’s Disease

Mickael Audrain , Benoit Souchet , Sandro Alves , Romain Fol , Arthur Viodé , et al.
Cerebral Cortex, 2018, 28 (11), pp.3976-3993. ⟨10.1093/cercor/bhx260⟩
Journal articles hal-02324980v1

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

Sophie Ayciriex , Fathia Djelti , Jérome Braudeau , Eloise Hudry , Marc Dhenain , et al.
Brain - A Journal of Neurology , 2015, 138 (8), pp.2383 - 2398. ⟨10.1093/brain/awv166⟩
Journal articles hal-01779044v1

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

Marina Cavazzana-Calvo , Emmanuel Payen , Olivier Negre , Gary Wang , Kathleen Hehir , et al.
Nature, 2010, 467 (7313), pp.318-322. ⟨10.1038/nature09328⟩
Journal articles cea-00905288v1

Intracerebral gene therapy in children with metachromatic leukodystrophy: Results of a phase I/II trial

Caroline Sevin , Thomas Roujeau , Nathalie Cartier , Thomas Baugnon , Catherine Adamsbaum , et al.
14. Annual WORLD Symposium (WORLD Symposium 2018), Feb 2018, San Diego, Californie, United States. 173 p., ⟨10.1016/j.ymgme.2017.12.352⟩
Conference papers hal-02737676v1
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CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

Lydie Boussicault , Sandro Alves , Antonin Lamazière , Anabelle Planques , Nicolas Heck , et al.
Brain - A Journal of Neurology , 2016, 139 (3), pp.953-970. ⟨10.1093/brain/awv384⟩
Journal articles hal-01299208v1
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Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice

Benoit Souchet , Mickael Audrain , Jean Marie Billard , Julien Dairou , Romain Fol , et al.
Acta Neuropathologica Communications, 2019, 7 (1), pp.46. ⟨10.1186/s40478-019-0678-6⟩
Journal articles hal-02324924v1
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Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins

Sandro Alves , Thibaut Marais , Maria-Grazia Biferi , Denis Furling , Martina Marinello , et al.
Molecular Neurodegeneration, 2016, 11, pp.58. ⟨10.1186/s13024-016-0123-2⟩
Journal articles hal-01371536v1

Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis

Sophie Ayciriex , Fathia Djelti , Sandro Alves , Anne Regazzetti , Mathieu Gaudin , et al.
Frontiers in Molecular Neuroscience, 2017, 10, ⟨10.3389/fnmol.2017.00211⟩
Journal articles hal-03220550v1
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Hematopoietic stem cell Gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

Nathalie Cartier , Salima Hacein-Bey-Abina , Cynthia C. Bartholomae , Gabor Veres , Manfred Schmidt , et al.
Science, 2009, 326 (5954), pp.818-823. ⟨10.1126/science.1171242⟩
Journal articles cea-00817492v1
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Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.

Mickael Audrain , Romain Fol , Patrick Dutar , Brigitte Potier , Jean-Marie Billard , et al.
Molecular Neurodegeneration, 2016, 11 (1), pp.5. ⟨10.1186/s13024-016-0070-y⟩
Journal articles inserm-01322473v1
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Intra-CSF AAV9 and AAVrh10 Administration in Nonhuman Primates: Promising Routes and Vectors for Which Neurological Diseases?

Karim Bey , Johan Deniaud , Laurence Dubreil , Béatrice Joussemet , Joseph Cristini , et al.
Molecular Therapy - Methods and Clinical Development, 2020, 17, pp.771-784. ⟨10.1016/j.omtm.2020.04.001⟩
Journal articles hal-02561949v1
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Reply: Beneficial effect of interleukin-2-based immunomodulation in Alzheimer-like pathology

Sandro Alves , Guillaume Churlaud , David Klatzmann , Nathalie Cartier
Brain - A Journal of Neurology , 2017, 140 (7), pp.e40 - e40. ⟨10.1093/brain/awx109⟩
Journal articles inserm-01617417v1
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Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer’s disease mice

Sandro Alves , Guillaume Churlaud , Mickael Audrain , Kristin Michaelsen-Preusse , Romain Fol , et al.
Brain - A Journal of Neurology , 2016, ⟨10.1093/brain/aww330⟩
Journal articles hal-01430973v1
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Real-Time Monitoring of Exosome Enveloped-AAV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain

Nicola Salvatore Orefice , Benoît Souchet , Jérôme Braudeau , Sandro Alves , Françoise Piguet , et al.
Molecular Therapy - Methods and Clinical Development, 2019, 14, pp.237 - 251. ⟨10.1016/j.omtm.2019.06.005⟩
Journal articles cea-02997523v1