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Domains : chim.ther

CD4 mimetics sensitize HIV-1-infected cells to ADCC

Jonathan Richard , Maxime Veillette , Nathalie Brassard , Shilpa Iyer , Michel Roger , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (20), pp.E2687-E2694. ⟨10.1073/pnas.1506755112⟩
Journal articles hal-02530884v1

M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures

Giuseppina Musumeci , Isabella Bon , David Lembo , Valeria Cagno , Maria Carla Re , et al.
Scientific Reports, 2017, 7 (1), ⟨10.1038/srep41018⟩
Journal articles hal-02530919v1

Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia

Pierre Regenass , Dayana Abboud , Francois Daubeuf , Christine Lehalle , Patrick Gizzi , et al.
Journal of Medicinal Chemistry, 2018, 61 (17), pp.7671-7686. ⟨10.1021/ACS.JMEDCHEM.8B00657⟩
Journal articles hal-02366281v1
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A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

Bérénice Hatat , Samir Yahiaoui , Cédric Lecoutey , Audrey Davis , Thomas Freret , et al.
Frontiers in Aging Neuroscience, 2019, 11, pp.148. ⟨10.3389/fnagi.2019.00148⟩
Journal articles hal-02399864v1

Solvent exchanges among molecular compounds. Two extreme cases of pharmaceutical interest

F. Mallet , S. Petit , S. Lafont , P. Billot , Dany Lemarchand , et al.
Journal of Thermal Analysis and Calorimetry, 2003, 73 (2), pp.459 - 471. ⟨10.1023/A:1025413709852⟩
Journal articles istex hal-01936076v1
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The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides

Xin Ming , Kyle Carver , Michael Fisher , Romain Noël , Jean-Christophe Cintrat , et al.
Nucleic Acids Research, 2013, 41 (6), pp.3673-3687. ⟨10.1093/nar/gkt066⟩
Journal articles cea-02432369v1

P19-23. Putative prefusion mechanism of HIV-1 Env revealed by ligand-induced quaternary alterations in o-gp140 trimers

Cg Moscoso , E Kan , S Poon , Y. Sun , Loïc M Martin , et al.
Retrovirology, 2009, 6 (Suppl 3), pp.P343. ⟨10.1186/1742-4690-6-S3-P343⟩
Journal articles hal-02542974v1

Crystal Structure of the Broadly Cross-Reactive HIV-1-Neutralizing Fab X5 and Fine Mapping of Its Epitope † , ‡

Ramalakshmi Darbha , Sanjay Phogat , Aran Labrijn , Yuuei Shu , Yijun Gu , et al.
Biochemistry, 2004, 43 (6), pp.1410-1417. ⟨10.1021/bi035323x⟩
Journal articles istex hal-02543015v1

Structural Studies of the Complex Between Akt-in and the Akt2-PH Domain Suggest that the Peptide Acts as an Allosteric Inhibitor of the Akt Kinase

Virginie Ropars , Philippe Barthe , Chi-Shien Wang , Wenlung Chen , Der-Lii Tzou , et al.
The Open Spectroscopy Journal, 2009, 3 (1), pp.65-76. ⟨10.2174/1874383800903010065⟩
Journal articles hal-02543033v1

Quaternary structures of HIV Env immunogen exhibit conformational vicissitudes and interface diminution elicited by ligand binding

C. Moscoso , Y. Sun , S. Poon , L. Xing , E. Kan , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (15), pp.6091-6096. ⟨10.1073/pnas.1016113108⟩
Journal articles cea-02530515v1

Interfacial Cavity Filling To Optimize CD4–Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein

Laurence Morellato-Castillo , Priyamvada Acharya , Olivier Combes , Johan Michiels , Anne Descours , et al.
Journal of Medicinal Chemistry, 2013, 56 (12), pp.5033-5047. ⟨10.1021/jm4002988⟩
Journal articles hal-02530667v1
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Conception et synthèse de micelles polymérisées pour le diagnostic et la thérapie de tumeurs

Anaëlle Doerflinger
Chimie organique. Université Paris-Saclay, 2017. Français. ⟨NNT : 2017SACLS287⟩
Theses tel-01620570v1
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Thermal properties measurements of a silica/pyrocarbon composite at the microscale

Indrayush De , Jean-Luc Battaglia , Gérard Vignoles
Journal of Applied Physics, 2016, 120 (24), pp.245101. ⟨10.1063/1.4972974⟩
Journal articles hal-01761320v1
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Emission of gas and Al2O3 smoke in gas-Al particle deflagration: experiments and emission modeling for explosive fireballs

Isabelle Ranc-Darbord , Gerard Baudin , Marc Genetier , David Ramel , Pierre Vasseur , et al.
International Journal of Thermophysics, 2018, 39 (3), pp.36. ⟨10.1007/s10765-018-2360-9⟩
Journal articles hal-02304920v1

Synthesis and anti-HIV properties of new hydroxyquinoline–polyamine conjugates on cells infected by HIV-1 LAV and HIV-1 BaL viral strains

Vincent Moret , Nathalie Dereudre-Bosquet , Pascal Clayette , Younes Laras , Nicolas Pietrancosta , et al.
Bioorganic and Medicinal Chemistry Letters, 2006, 16 (23), pp.5988-5992. ⟨10.1016/j.bmcl.2006.08.114⟩
Journal articles istex hal-02351693v1
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Screening for pancreatic lipase natural modulators by capillary electrophoresis hyphenated to spectrophotometric and conductometric dual detection

Ghassan Al Hamoui Dit Banni , Rouba Nasreddine , Syntia Fayad , Phu Cao-Ngoc , Jean-Christophe Rossi , et al.
Analyst, 2021, 146 (4), pp.1386-1401. ⟨10.1039/d0an02234a⟩
Journal articles hal-03835824v1

Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein

C. Vita , E. Drakopoulou , J. Vizzavona , S. Rochette , Lilian Martin , et al.
Proceedings of the National Academy of Sciences of the United States of America, 1999, 96 (23), pp.13091-13096. ⟨10.1073/pnas.96.23.13091⟩
Journal articles hal-02528538v1

Role of Disulfide Bonds in Folding and Activity of Leiurotoxin I: Just Two Disulfides Suffice

Qi Zhu , Songping Liang , Loïc M Martin , Sylvaine Gasparini , André Ménez , et al.
Biochemistry, 2002, 41 (38), pp.11488-11494. ⟨10.1021/bi026136m⟩
Journal articles istex hal-02528546v1

Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein

François Stricher , Chih-Chin Huang , Anne Descours , Sophie Duquesnoy , Olivier Combes , et al.
Journal of Molecular Biology, 2008, 382 (2), pp.510-524. ⟨10.1016/j.jmb.2008.06.069⟩
Journal articles hal-02528576v1

Raman spectroscopy study of nitromethane in a shear diamond anvil cell

Philippe Hébert , Aude Isambert , Jean-Pierre Petitet , Andreas Zerr
High Pressure Research, 2010, 30, pp.24-27. ⟨10.1080/08957950903513796⟩
Journal articles insu-03605339v1
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Design et fonctionnalisation d’hétérocycles originaux de type bicycliques [5-5] et tricycliques [6-5-6] à visée thérapeutique potentielle

Abdelaziz Ejjoummany
Chimie organique. Université d'Orléans; Université Hassan II (Casablanca, Maroc), 2020. Français. ⟨NNT : 2020ORLE3141⟩
Theses tel-03709731v1

RNA-based drugs: discovery and design, From aptamers to oligonucleotides: a perspective for in silico approaches

Fabrice Leclerc
Doctoral. France. 2020
Lectures hal-03313797v1
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Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors

Bruno Oyallon , Marie Brachet-Botineau , Cédric Logé , Pascal Bonnet , Mohamed Souab , et al.
European Journal of Medicinal Chemistry, 2018, 154, pp.101-109. ⟨10.1016/j.ejmech.2018.04.056⟩
Journal articles hal-03408667v1
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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

Jean Jacques Vanden Eynde , Arduino A Mangoni , Jarkko Rautio , Jérôme Leprince , Yasu-Taka Azuma , et al.
Molecules, 2019, 25 (1), pp.119. ⟨10.3390/molecules25010119⟩
Journal articles hal-03321491v1

Ongoing NEA scientific activities related to advanced fuel cycles

Stéphanie Cornet , Nathalie Chauvin , Davide Costa , Tatyana Ivanova
GLOBAL 2019 - International Nuclear Fuel Cycle Conference and TOP FUEL 2019 - Light Water Reactor Fuel Performance Conference,, Sep 2019, Seattle, United States
Conference papers hal-03132831v1

Benchmark study on fuel performance codes for fast reactors

Nathalie Chauvin
GLOBAL 2019 - International Nuclear Fuel Cycle Conference and TOP FUEL 2019 - Light Water Reactor Fuel Performance Conference, Sep 2019, Seattle, France
Conference papers hal-03132840v1

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

Elisabet Viayna , Nicolas Coquelle , Monika Cieslikiewicz-Bouet , Pedro Cisternas , Carolina Oliva , et al.
Journal of Medicinal Chemistry, 2020, ⟨10.1021/acs.jmedchem.0c01775⟩
Journal articles hal-03094189v1
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Synthesis of acyclic nucleoside phosphonates targeting Flavin-Dependent Thymidylate Synthase in Mycobacterium tuberculosis

Nicolas G Biteau , Vincent Roy , J.-C. Lambry , Hubert F Becker , Hannu Myllykallio , et al.
Bioorganic & Medicinal Chemistry Letters, 2021, 46, pp.116351. ⟨10.1016/j.bmc.2021.116351⟩
Journal articles hal-03322503v1
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Polymer encapsulation of ruthenium complexes for biological and medicinal applications

Elise Villemin , Yih Ching Ong , Christophe M Thomas , Gilles Gasser
Nature Reviews Chemistry, 2019, 3 (4), pp.261-282. ⟨10.1038/s41570-019-0088-0⟩
Journal articles hal-02352951v1

Integrative Model of Rhodanine Derivatives as Tau- aggregation inhibitors in AD

Fabrice Leclerc , Yoanna Álvarez Ginarte
7th International Chemistry Symposium SIQ - SEADIM / 12th Molecular Design and Bioinformatics Symposium, Jun 2019, Cayo Santa María, Cuba
Conference papers hal-02324217v1