Chronic smoking and cognition in patients with schizophrenia: A meta-analysis - CEA - Commissariat à l’énergie atomique et aux énergies alternatives Accéder directement au contenu
Article Dans Une Revue Schizophrenia Research Année : 2020

Chronic smoking and cognition in patients with schizophrenia: A meta-analysis

Résumé

Background: Patients with schizophrenia display a very high rate of smoking in comparison with the general population. The aim of the present meta-analysis was to assess the association between cognitive performances and smoking status in patients with schizophrenia.Methods: This review was registered at PROSPERO, number CRD42019126758. After a systematic search on MEDLINE, PsycINFO, and clinicaltrials.gov databases, all studies measuring neurocognitive performances in both smoking and nonsmoking patients with a diagnosis of schizophrenia were included. Original data were extracted. Standardized mean differences (SMD) were calculated with the means and standard deviations extracted using a random-effect model. Cognitive performances were compared between smoking and nonsmoking patients with schizophrenia. Meta-regressions were performed to explore the influence of sociodemographic and clinical variables on SMD.Results: Eighteen studies were included in this meta-analysis. Chronic smoking in patients with schizophrenia, compared to nonsmoking, was associated with a significant more important impairment in attention (p = 0.02), working memory (p < 0.001), learning (p < 0.001), executive function (EF) reasoning/problem solving (p < 0.001) and speed of processing (p < 0.001), but not in delayed memory, EF abstraction/shifting, EF inhibition and language. The meta-regression analysis found that attention impairment could be influenced by age (p < 0.001) and Positive and Negative Syndrome Scale (PANSS) total score (p = 0.006).Conclusions: This meta-analysis provides strong evidence that, in patients with schizophrenia, chronic smoking is related to cognitive impairment. This association emphasizes the importance of paying careful attention to both tobacco addiction and cognitive functioning in patients with schizophrenia.
Fichier principal
Vignette du fichier
S0920996420301821.pdf (477.4 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03493258 , version 1 (17-10-2022)

Licence

Identifiants

Citer

Nicolas Coustals, Catherine Martelli, Marine Brunet-Lecomte, Amélie Petillion, Bruno Romeo, et al.. Chronic smoking and cognition in patients with schizophrenia: A meta-analysis. Schizophrenia Research, 2020, 222, pp.113 - 121. ⟨10.1016/j.schres.2020.03.071⟩. ⟨hal-03493258⟩
21 Consultations
313 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More