Diagnostic value of striatal 18F-FP-DTBZ PET in Parkinson’s disease - CEA - Commissariat à l’énergie atomique et aux énergies alternatives Accéder directement au contenu
Article Dans Une Revue Frontiers in Aging Neuroscience Année : 2022

Diagnostic value of striatal 18F-FP-DTBZ PET in Parkinson’s disease

Xiu-Lin Liu
  • Fonction : Auteur
Shu-Ying Liu
  • Fonction : Auteur
Gilles Tamagnan
  • Fonction : Auteur
Hong-Wen Qiao
  • Fonction : Auteur
Tian-Bin Song
  • Fonction : Auteur
Jie Lu
  • Fonction : Auteur
Piu Chan
  • Fonction : Auteur

Résumé

Background 18 F-FP-DTBZ has been proven as a biomarker for quantifying the concentration of presynaptic vesicular monoamine transporter 2 (VMAT2). However, its clinical application is still limited. Objectives To evaluate the difference in dopaminergic integrity between patients with Parkinson’s disease (PD) and healthy controls (HC) using 18 F-FP-DTBZ PET in vivo and to determine the diagnostic value of standardized uptake value ratios (SUVRs) using the Receiver Operating Characteristic (ROC) curve. Methods A total of 34 PD and 31 HC participants were enrolled in the PET/MR derivation cohort, while 89 PD and 18 HC participants were recruited in the PET/CT validation cohort. The Hoehn–Yahr Scale and the third part of the MDS-Unified Parkinson’s Disease Rating Scale (MDSUPDRS-III) were used to evaluate the disease staging and severity. All assessments and PET scanning were performed in drug-off states. The striatum was segmented into five subregions as follows: caudate, anterior dorsal putamen (ADP), anterior ventral putamen (AVP), posterior dorsal putamen (PDP), and posterior ventral putamen (PVP) using automatic pipeline built with the PMOD software (version 4.105). The SUVRs of the targeted subregions were calculated using the bilateral occipital cortex as the reference region. Results Regarding the diagnostic value, ROC curve and blind validation showed that the contralateral PDP (SUVR = 3.43) had the best diagnostic accuracy (AUC = 0.973; P < 0.05), with a sensitivity of 97.1% (95% CI: 82.9–99.8%), specificity of 100% (95% CI: 86.3–100%), positive predictive value (PPV) of 100% (95% CI: 87.0–100%), negative predictive value (NPV) of 96.9% (95% CI: 82.0–99.8%), and an accuracy of 98.5% for the diagnosis of PD in the derivation cohort. Blind validation of 18 F-FP-DTBZ PET imaging diagnosis was done using the PET/CT cohort, where participants with a SUVR of the PDP <3.43 were defined as PD. Kappa test showed a consistency of 0.933 ( P < 0.05) between clinical diagnosis and imaging diagnosis, with a sensitivity of 98.9% (95% CI: 93.0–99.9%), specificity of 94.4% (95% CI: 70.6–99.7%), PPV of 98.9% (95% CI: 93.0–99.9%), NPV of 94.4% (95% CI: 70.6–99.7%), and a diagnostic accuracy of 98.1%. Conclusions Our results showed that an SUVR threshold of 3.43 in the PDP could effectively distinguish patients with PD from HC.

Dates et versions

cea-04471454 , version 1 (21-02-2024)

Identifiants

Citer

Xiu-Lin Liu, Shu-Ying Liu, Olivier Barret, Gilles Tamagnan, Hong-Wen Qiao, et al.. Diagnostic value of striatal 18F-FP-DTBZ PET in Parkinson’s disease. Frontiers in Aging Neuroscience, 2022, 14, ⟨10.3389/fnagi.2022.931015⟩. ⟨cea-04471454⟩
3 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More