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Article Dans Une Revue Journal of Neuroinflammation Année : 2022

Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study

Tian-Bin Song
  • Fonction : Auteur
Xiu-Lin Liu
  • Fonction : Auteur
Yun-Xia Yao
  • Fonction : Auteur
Chun-Song Zhao
  • Fonction : Auteur
Sheng-Li Xu
  • Fonction : Auteur
Yan-Ning Cai
  • Fonction : Auteur
Gilles Tamagnan
  • Fonction : Auteur
Vesna Sossi
  • Fonction : Auteur

Résumé

Abstract Background Abnormal activation of immune system is an important pathogenesis of Parkinson’s disease, but the relationship between peripheral inflammation, central microglia activation and dopaminergic degeneration remains unclear. Objectives To evaluate the brain regional microglia activation and its relationship with clinical severity, dopaminergic presynaptic function, and peripheral inflammatory biomarkers related to adaptive immunity. Methods In this case–control study, we recruited 23 healthy participants and 24 participants with early-stage Parkinson’s disease. 18 F-PBR06 PET/MR for microglia activation, 18 F-FP-DTBZ for dopaminergic denervation, total account of T cells and subpopulations of T helper (Th1/Th2/Th17) cells, and the levels of serum inflammatory cytokines were assessed. Sanger sequencing was used to exclude the mix-affinity binders of 18 F-PBR06-PET. Results Compared to healthy controls, patients with Parkinson’s disease had an increased 18 F-PBR06-PET standardized uptake value ratio (SUVR) in the putamen, particularly in the ipsilateral side of the motor onset. 18 F-PBR06-PET SUVR was positively associated with 18 F-FP-DTBZ-PET SUVR in the brainstem and not associated with disease severity measured by Hoehn and Yahr stage, MDS-UPDRS III scores. Patients with Parkinson’s disease had elevated frequencies of Th1 cells and serum levels of IL10 and IL17A as compared to healthy controls. No significant association between peripheral inflammation markers and microglia activation in the brain of PD was observed. Conclusion Parkinson’s disease is associated with early putaminal microglial activation and peripheral phenotypic Th1 bias. Peripheral adaptive immunity might be involved in microglia activation in the process of neurodegeneration in PD indirectly, which may be a potential biomarker for the early detection and the target for immunomodulating therapy.

Dates et versions

cea-04471442 , version 1 (21-02-2024)

Identifiants

Citer

Tian-Bin Song, Xiu-Lin Liu, Yun-Xia Yao, Chun-Song Zhao, Olivier Barret, et al.. Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study. Journal of Neuroinflammation, 2022, 19 (1), pp.209. ⟨10.1186/s12974-022-02574-z⟩. ⟨cea-04471442⟩
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