Insights into human genetic variation and population history from 929 diverse genomes - CEA - Commissariat à l’énergie atomique et aux énergies alternatives
Article Dans Une Revue Science Année : 2020

Insights into human genetic variation and population history from 929 diverse genomes

Résumé

Genome sequences from diverse human groups are needed to understand the structure of genetic variation in our species and the history of, and relationships between, different populations. We present 929 high-coverage genome sequences from 54 diverse human populations, 26 of which are physically phased using linked-read sequencing. Analyses of these genomes reveal an excess of previously undocumented common genetic variation private to southern Africa, central Africa, Oceania, and the Americas, but an absence of such variants fixed between major geographical regions. We also find deep and gradual population separations within Africa, contrasting population size histories between hunter-gatherer and agriculturalist groups in the past 10,000 years, and a contrast between single Neanderthal but multiple Denisovan source populations contributing to present-day human populations.
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Dates et versions

cea-04419421 , version 1 (18-06-2024)

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Anders Bergstrom, Shane A. Mccarthy, Ruoyun Hui, Mohamed A. Almarri, Qasim Ayub, et al.. Insights into human genetic variation and population history from 929 diverse genomes. Science, 2020, 367 (6484), pp.eaay5012. ⟨10.1126/science.aay5012⟩. ⟨cea-04419421⟩
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