Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth
Todd M. Everson
(1)
,
Marta Vives-Usano
(2, 3, 4)
,
Emie Seyve
(5)
,
Andres Cardenas
(6, 7)
,
Marina Lacasana
(8, 9)
,
Jeffrey M. Craig
(10, 11, 12)
,
Corina Lesseur
(13)
,
Emily R. Baker
(14)
,
Nora Fernandez-Jimenez
(15, 16)
,
Barbara Heude
(17)
,
Patrice Perron
(18)
,
Beatriz Gonzalez-Alzaga
(9)
,
Jane Halliday
(10, 11)
,
Maya A. Deyssenroth
(13)
,
Margaret R. Karagas
(14)
,
Carmen Iniguez
(8, 19, 20, 21)
,
Luigi Bouchard
(22)
,
Pedro Carmona-Saez
(23)
,
Yuk J. Loke
(10)
,
Ke Hao
(13)
,
Thalia Belmonte
(24)
,
Marie A. Charles
(17)
,
Jordi Martorell-Marugan
(23)
,
Evelyne Muggli
(11, 10)
,
Jia Chen
(13)
,
Mariana F. Fernandez
(2, 23)
,
Jorg Tost
(25)
,
Antonio Gomez-Martin
(23)
,
Stephanie J. London
(26)
,
Jordi Sunyer
(4, 8, 27, 28)
,
Carmen J. Marsit
(1)
,
Johanna Lepeule
(5)
,
Marie-France Hivert
(6, 29)
,
Mariona Bustamante
(2, 4, 8, 27)
1
Emory University [Atlanta, GA]
2 CRG-UPF - Center for Genomic Regulation
3 BIST - Barcelona Institute of Science and Technology
4 UPF - Universitat Pompeu Fabra [Barcelona]
5 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
6 HMS - Harvard Medical School [Boston]
7 School of Public Health [Berkeley]
8 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
9 Andalusian School of Public Health [Granada]
10 MCRI - Murdoch Children's Research Institute
11 Department of Paediatrics [Melbourne]
12 Deakin University [Burwood]
13 MSSM - Icahn School of Medicine at Mount Sinai [New York]
14 Geisel School of Medicine at Dartmouth
15 UPV / EHU - University of the Basque Country = Euskal Herriko Unibertsitatea
16 Biocruces Bizkaia Health Research Institute [Baracaldo]
17 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
18 UdeS - Université de Sherbrooke
19 UV - Universitat de València
20 FISABIO - Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne]
21 Universitat Jaume I = Jaume I University
22 Department of Biochemistry and Functional Genomics
23 UGR - Universidad de Granada = University of Granada
24 University of Oviedo
25 LEE - Laboratoire Epigénétique et environnement
26 NIEHS-NIH - National Institute of Environmental Health Sciences [Durham, NC, USA]
27 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
28 IMIM-Hospital del Mar
29 Massachusetts General Hospital [Boston]
2 CRG-UPF - Center for Genomic Regulation
3 BIST - Barcelona Institute of Science and Technology
4 UPF - Universitat Pompeu Fabra [Barcelona]
5 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
6 HMS - Harvard Medical School [Boston]
7 School of Public Health [Berkeley]
8 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
9 Andalusian School of Public Health [Granada]
10 MCRI - Murdoch Children's Research Institute
11 Department of Paediatrics [Melbourne]
12 Deakin University [Burwood]
13 MSSM - Icahn School of Medicine at Mount Sinai [New York]
14 Geisel School of Medicine at Dartmouth
15 UPV / EHU - University of the Basque Country = Euskal Herriko Unibertsitatea
16 Biocruces Bizkaia Health Research Institute [Baracaldo]
17 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
18 UdeS - Université de Sherbrooke
19 UV - Universitat de València
20 FISABIO - Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne]
21 Universitat Jaume I = Jaume I University
22 Department of Biochemistry and Functional Genomics
23 UGR - Universidad de Granada = University of Granada
24 University of Oviedo
25 LEE - Laboratoire Epigénétique et environnement
26 NIEHS-NIH - National Institute of Environmental Health Sciences [Durham, NC, USA]
27 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
28 IMIM-Hospital del Mar
29 Massachusetts General Hospital [Boston]
Andres Cardenas
- Fonction : Auteur
Carmen Iniguez
- Fonction : Auteur
Jordi Sunyer
- Fonction : Auteur
Mariona Bustamante
- Fonction : relator_rsp
- PersonId : 1094206
Résumé
Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.
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