In order to carry out strontium isotope analysis, glass artifacts from South Asia were sampled with portable laser (pLA), a relatively novel sampling technique, that leaves damages invisible to the naked eye. Subsequently, thermal ionization mass spectrometry (TIMS) was used to obtain strontium isotope ratios after sample dissolution and separation. With this study, the goal was two-fold: to determine whether the measurements of strontium isotope ratios were impacted by using a portable laser as a sample tool, and also to assess the pertinence of using strontium isotope ratios to provenance Indian glass. Despite a deterioration of the precision of the measurement of the strontium isotope ratios for artifacts sampled with pLA compared to traditional sampling method, the strontium isotope ratios of certain Indian glass are so different that this does not affect their separation but comparison of datasets obtained using standard methods and pLA might be challenging.