%0 Journal Article %T A new paradigm for high-sensitivity 19 F magnetic resonance imaging of perfluorooctylbromide %+ Laboratoire d'Imagerie et de Spectroscopie (LRMN) %+ Service NEUROSPIN (NEUROSPIN) %+ Service Hospitalier Frédéric Joliot (SHFJ) %+ Liquides Ioniques et Interfaces Chargées (LI2C) %+ Laboratoire Guerbet / Guerbet Research %A Giraudeau, Céline %A Flament, Julien %A Marty, Benjamin %A Boumezbeur, Fawzi %A Mériaux, Sébastien %A Robic, Caroline %A Port, Marc %A Tsapis, Nicolas %A Fattal, Elias %A Giacomini, Eric %A Lethimonnier, Franck %A Le Bihan, Denis %A Valette, Julien %< avec comité de lecture %@ 0740-3194 %J Magnetic Resonance in Medicine %I Wiley %V 63 %N 4 %P 1119-1124 %8 2010-05 %D 2010 %R 10.1002/mrm.22269 %M 20373415 %Z Physics [physics]Journal articles %X In the present work, the NMR properties of perfluorooctylbromide are revisited to derive a high-sensitivity fluorine MRI strategy. It is shown that the harmful effects of J-coupling can be eliminated by carefully choosing the bandwidth of the 180 degrees pulses in a spin-echo sequence. The T(2) of the CF(3) resonance of the molecule is measured using a multispin-echo sequence and shown to dramatically depend on the interpulse delay. Following these observations, an optimized multispin-echo imaging sequence is derived and compared with short TE/pulse repetition time gradient echo and chemical shift imaging sequences. The unparalleled sensitivity yielded by the multispin-echo sequence is promising for future applications, in particular for targeted contrast agents such as perfluorooctylbromide nanoparticles. %G English %L cea-02397769 %U https://cea.hal.science/cea-02397769 %~ CEA %~ UPMC %~ ESPCI %~ CNRS %~ PARISTECH %~ PSL %~ UNIV-PARIS-SACLAY %~ JOLIOT %~ CEA-DRF %~ SHFJ %~ NEUROSPIN %~ SORBONNE-UNIVERSITE %~ SU-SCIENCES %~ SU-SCI %~ ESPCI-PSL %~ SU-TI %~ ALLIANCE-SU