%0 Journal Article %T Improving I-131 Radioiodine Therapy By Hybrid Polymer-Grafted Gold Nanoparticles %+ Laboratoire Innovation en Chimie des Surfaces et NanoSciences (LICSEN UMR 3685) %+ Transporteurs et Imagerie, Radiothérapie en Oncologie et Mécanismes biologiques des Altérations du Tissu Osseux (TIRO-MATOs - UMR E4320) %+ Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL) %+ Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire (LIONS) %+ Département de Radio-Oncologie [Baclesse, Caen] %A Le Goas, Marine %A Paquet, Marie %A Paquirissamy, Aurélie %A Guglielmi, Julien %A Compin, Cathy %A Thariat, Juliette %A Vassaux, Georges %A Geertsen, Valérie %A Humbert, Olivier %A Renault, Jean-Philippe %A Carrot, Géraldine %A Pourcher, Thierry %A Cambien, Beatrice %Z INSERM Institut National de la Sante et de la Recherche Medicale (Inserm) %Z French National Research AgencyFrench National Research Agency (ANR) [14IAS001MCSR] %Z CEA French Atomic Energy Commission [A-PTTOX-02-52-03] %< avec comité de lecture %@ 1178-2013 %J International Journal of Nanomedicine %V 14 %P 7933-7946 %8 2019 %D 2019 %R 10.2147/IJN.S211496 %K internal radioisotope therapy %K radioiodine %K polymer-grafted gold nanoparticles %K melanoma %K colorectal cancer %K radio-enhancement %Z Computer Science [cs]/Digital Libraries [cs.DL]Journal articles %X Background Human trials combining external radiotherapy (RT) and metallic nanoparticles are currently underway in cancer patients. For internal RT, in which a radioisotope such as radioiodine is systemically administered into patients, there is also a need for enhancing treatment efficacy, decreasing radiation-induced side effects and overcoming radio-resistance. However, if strategies vectorising radioiodine through nanocarriers have been documented, sensitizing the neoplasm through the use of nanotherapeutics easily translatable to the clinic in combination with the standard systemic radioiodine treatment has not been assessed yet. Method and materials The present study explored the potential of hybrid poly (methacrylic acid)-grafted gold nanoparticles to improve the performances of systemic I-131-mediated RT on cancer cells and in tumor-bearing mice. Such nanoparticles were chosen based on their ability previously described by our group to safely withstand irradiation doses while exhibiting good biocompatibility and enhanced cellular uptake. Results In vitro clonogenic assays performed on melanoma and colorectal cancer cells showed that poly(methacrylic acid)-grafted gold nanoparticles (PMAA-AuNPs) could efficiently lead to a marked tumor cell mortality when combined to a low activity of radioiodine, which alone appeared to be essentially ineffective on tumor cells. In vivo, tumor enrichment with PMAA-AuNPs significantly enhanced the killing potential of a systemic radioiodine treatment. Conclusion This is the first report of a simple and reliable nanomedicine-based approach to reduce the dose of radioiodine required to reach curability. In addition, these results open up novel perspectives for using high-Z metallic NPs in additional molecular radiation therapy demonstrating heterogeneous dose distributions. %G English %L cea-02316811 %U https://cea.hal.science/cea-02316811 %~ CEA %~ UNICE %~ CNRS %~ COMUE-NORMANDIE %~ PUBNIMBE %~ DSV %~ INC-CNRS %~ IRAMIS-NIMBE %~ CEA-UPSAY %~ UNIV-PARIS-SACLAY %~ CEA-UPSAY-SACLAY %~ UNIV-COTEDAZUR %~ JOLIOT %~ CEA-DRF %~ SHFJ %~ CEA-CAD %~ BIAM %~ TEST-HALCNRS %~ GS-ENGINEERING %~ IRAMIS %~ GS-CHIMIE %~ GS-PHYSIQUE %~ INSTITUT-SCIENCES-LUMIERE