%0 Journal Article %T XNA ligation using T4 DNA ligase in crowding conditions %+ Rega Institute for Medical Research [Leuven, België] %+ Birkbeck College [University of London] %+ University College of London [London] (UCL) %+ Génomique métabolique (UMR 8030) %A Kestemont, Donaat %A Renders, Marleen %A Leonczak, Piotr %A Abramov, Mikhail %A Schepers, Guy %A Pinheiro, Vitor B. %A Rozenski, Jef %A Herdewijn, Piet %Z FWO-Flanders Research Foundation [1247114N] %Z Research Fund KU Leuven [OT/14/128] %< avec comité de lecture %@ 1359-7345 %J Chemical Communications %I Royal Society of Chemistry %V 54 %N 49 %P 6408-6411 %8 2018 %D 2018 %R 10.1039/c8cc02414f %M 29872779 %Z Life Sciences [q-bio]Journal articles %X T4 DNA ligase is capable of ligating 2OMe-RNA duplexes, HNA, LNA and FANA mixed sequences in the presence of 10% w/v PEG8000 and 3 M betaine. The enzymatic joining of oligonucleotides containing multiple consecutive XNA nucleotides at the ligation site has not been reported before. %G English %L cea-02291354 %U https://cea.hal.science/cea-02291354 %~ CEA %~ CNRS %~ UNIV-EVRY %~ OPENAIRE %~ DSV-IG %~ DSV %~ CEA-UPSAY %~ GENOMIQUE-METABOLIQUE %~ UNIV-PARIS-SACLAY %~ UNIV-EVRY-SACLAY %~ CEA-UPSAY-SACLAY %~ JACOB %~ CEA-DRF %~ GENOSCOPE %~ TEST-HALCNRS %~ GS-BIOSPHERA