%0 Journal Article %T Microglia affect $\alpha$-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease %+ Center for neurodegenerative Science, Van Andel Research Institute %+ Van Andel Institute [Grand Rapids] %+ Center for Neurodegenerative Science, Van Andel Research Institute %+ Laboratoire des Maladies Neurodégénératives - UMR 9199 (LMN) %+ Optical Image Core, Van Andel Research Institute %+ Bioinformatics and Biostatistics Core, Van Andel Research Institute %A George, Sonia %A Rey, Nolwen %A Tyson, Trevor %A Esquibel, Corinne %A Meyerdirk, Lindsay %A Schulz, Emily %A Pierce, Steven %A Burmeister, Amanda, R %A Madaj, Zachary %A Steiner, Jennifer, A %A Escobar Galvis, Martha, L %A Brundin, Lena %A Brundin, Patrik %< avec comité de lecture %@ 1750-1326 %J Molecular Neurodegeneration %I BioMed Central %V 14 %P 34 %8 2019-12 %D 2019 %R 10.1186/s13024-019-0335-3 %Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] %Z Life Sciences [q-bio]/Cellular Biology %Z Life Sciences [q-bio]/Biochemistry, Molecular BiologyJournal articles %X Background: Cell-to-cell propagation of α-synuclein ($\alpha$-syn) aggregates is thought to contribute to the pathogenesis of Parkinson's disease (PD) and underlie the spread of α-syn neuropathology. Increased pro-inflammatory cytokine levels and activated microglia are present in PD and activated microglia can promote α-syn aggregation. However, it is unclear how microglia influence α-syn cell-to-cell transfer. %G English %2 https://cea.hal.science/cea-02280706/document %2 https://cea.hal.science/cea-02280706/file/2019_alpha-synuclein%20spread_microglia_Rey_Brundin_MolNeurodegeneration.pdf %L cea-02280706 %U https://cea.hal.science/cea-02280706 %~ CEA %~ CNRS %~ CEA-UPSAY %~ INSERM-SACLAY %~ UNIV-PARIS-SACLAY %~ CEA-UPSAY-SACLAY %~ JACOB %~ CEA-DRF %~ MIRCEN %~ TEST-HALCNRS %~ GS-ENGINEERING