%0 Journal Article %T Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression %+ Institut de Biologie Intégrative de la Cellule (I2BC) %+ Department of Genetics [Stanford] %+ Saarland University [Saarbrücken] %+ Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis %+ Institut de Biologie et de Technologies de Saclay (IBITECS) %+ Génétique moléculaire et destin cellulaire (FRE 3377) %+ Centre National de Génotypage (CNG) %+ Service de Pharmacologie et Immunoanalyse (SPI) %+ National Cancer Institute [Bethesda] (NCI-NIH) %+ Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL) %+ Department of Radiotherapy and Radiation Oncology %A Contrepois, Kévin %A Coudereau, Clément %A Benayoun, Bérénice %A Schüler, Nadine %A Bischof, Oliver %A Courbeyrette, Régis %A Carvalho, Cyril %A Thuret, Jean-Yves %A Ma, Zhihai %A Derbois, Céline %A Nevers, Marie-Claire %A Volland, Hervé %A Redon, Christophe, E. %A Bonner, William, M. %A Deleuze, Jean-François %A Wiel, Clotilde %A Bernard, David %A Snyder, Michael, P. %A Rübe, Claudia, E. %A Olaso, Robert %A Fenaille, François %A Mann, Carl %Z Fondation pour la Recherche Medicale [DEP20131128527]; Association pour la Recherche sur le Cancer; Comite de l'Essonne de la Ligue Contre le Cancer; CEA Plasticity and Instability of the Genome Program; ARC foundation; Dean's fellowship at Stanford University; NIA [K99 AG049934]; German Research Foundation [RU 821/3-1]; European Atomic Energy Community's Seventh Framework Programme [249689]; NIH [5P01GM09913005, 5P50HG00773502]; Center for Cancer Research, National Cancer Institute, National Institutes of Health %< avec comité de lecture %@ 2041-1723 %J Nature Communications %I Nature Publishing Group %V 8 %P 14995 %8 2017-08 %D 2017 %R 10.1038/ncomms14995 %M 28489069 %Z Life Sciences [q-bio]/Cellular BiologyJournal articles %X The senescence of mammalian cells is characterized by a proliferative arrest in response to stress and the expression of an inflammatory phenotype. Here we show that histone H2A.J, a poorly studied H2A variant found only in mammals, accumulates in human fibroblasts in senescence with persistent DNA damage. H2A.J also accumulates in mice with aging in a tissue-specific manner and in human skin. Knock-down of H2A.J inhibits the expression of inflammatory genes that contribute to the senescent-associated secretory phenotype (SASP), and over expression of H2A.J increases the expression of some of these genes in proliferating cells. H2A.J accumulation may thus promote the signalling of senescent cells to the immune system, and it may contribute to chronic inflammation and the development of aging-associated diseases. %G English %2 https://cea.hal.science/cea-02143246/document %2 https://cea.hal.science/cea-02143246/file/Contr.pdf %L cea-02143246 %U https://cea.hal.science/cea-02143246 %~ PASTEUR %~ CEA %~ CNRS %~ UNIV-LYON1 %~ UNIV-PSUD %~ CNG %~ OPENAIRE %~ CEA-UPSAY %~ I2BC %~ UNIV-PARIS-SACLAY %~ UNIV-PSUD-SACLAY %~ CEA-UPSAY-SACLAY %~ JACOB %~ JOLIOT %~ CEA-DRF %~ DMTS %~ CRCL %~ UDL %~ UNIV-LYON %~ INRAE %~ TEST-HALCNRS %~ GS-ENGINEERING %~ GS-BIOSPHERA %~ GS-HEALTH-DRUG-SCIENCES %~ INSTITUT-SCIENCES-LUMIERE %~ ONO %~ FRM