Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents
Résumé
Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive
behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hyporesponsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a
longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether
neural activity in response to anticipated rewards predicts problematic drug use. We find that
diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical
(dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic
drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards
at age 14 also predicts problematic drug use at age 16, but the neural responses independently
predict more variance than psychometric measures. Together, these findings suggest that diminished
neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to
future problematic drug use.
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers produits par l'(les) auteur(s) |
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