%0 Journal Article %T Acoustic Transmission Factor through the Rat Skull as a Function of Body Mass, Frequency and Position %+ Service NEUROSPIN (NEUROSPIN) %A Gerstenmayer, Matthieu %A Fellah, Benjamin %A Magnin, Remi %A Selingue, Erwan %A Larrat, Benoit %Z The authors thank the CEA “Technologies for Health” transverse program, which funded this work %< avec comité de lecture %@ 0301-5629 %J Ultrasound in Medicine & Biology %I Elsevier %V 44 %N 11 %P 2336-2344 %8 2018-11 %D 2018 %R 10.1016/j.ultrasmedbio.2018.06.005 %K Acoustic transmission %K Insertion loss %K Rat skull %K Focused ultrasound %Z Life Sciences [q-bio]/Bioengineering %Z Engineering Sciences [physics] %Z Engineering Sciences [physics]/Acoustics [physics.class-ph]Journal articles %X In many transcranial ultrasound studies on rats, the transmission factor is assumed to be independent of animal weight and losses resulting from non-normal incidence angles of the beam are not accounted for. In this study, we measured acoustic transmission factors through 13 excised skulls of male Sprague-Dawley rats weighing between 90 and 520g, at different positions on each skull and at 1, 1.25, 1.5, 1.75 and 2MHz. Our results revealed that insertion loss through rat skull increases linearly with both body mass and frequency and strongly depends on the position, decreasing from the front to the back and from the midline to the lateral sides. Skull thickness also scales linearly with body mass. Reflection explains the main part of the insertion loss compared with attenuation and aberration. These data are helpful in predicting the acoustic pressure at the focus in the brain %G English %2 https://cea.hal.science/cea-02043267/document %2 https://cea.hal.science/cea-02043267/file/UMB_proof-Gerstenmayer2018.pdf %L cea-02043267 %U https://cea.hal.science/cea-02043267 %~ CEA %~ CEA-UPSAY %~ UNIV-PARIS-SACLAY %~ CEA-UPSAY-SACLAY %~ JOLIOT %~ CEA-DRF %~ NEUROSPIN %~ ANR %~ GS-ENGINEERING