Imaging probes and modalities for the study of Solute Carrier O (SLCO)-transport function in vivo
Résumé
Transporters of the Solute Carrier O (SLCO) family, former organic anion-transporting
polypeptides (OATP), are now recognized as key players in pharmacokinetics. Imaging
is increasingly regarded as a relevant method to elucidate and decipher the intrinsic
role of SLCO in controlling drug disposition in plasma and tissues. Current research in
this representative field of translational research is based on different imaging
modalities including nuclear imaging, such as Single Photon Emission Computed
Tomography (SPECT) or Positron Emission Tomography (PET), as well as Magnetic
Resonance Imaging (MRI). Imaging modalities can be compared in terms of sensitivity,
quantitative properties, spatial resolution, variety of ligands and radiation exposure. All
of these approaches rely on the use of SLCO-substrates that are detected using
corresponding modalities. The present review aims at reporting and comparing the
imaging probes that have been proposed to study SLCO-transport function, in terms
of $in\ vitro$ specificity, $in\ vivo$ behavior and clinical validation.
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