%0 Journal Article %T Slow magic-angle coil spinning: A high-sensitivity and high-resolution NMR strategy for microscopic biological specimens %+ Laboratoire Structure et Dynamique par Résonance Magnétique (LCF) (LSDRM) %A Wong, Alan %A M. Aguiar, Pedro %A Sakellariou, Dimitris %< avec comité de lecture %@ 0740-3194 %J Magnetic Resonance in Medicine %I Wiley %V 63 %P 269-274 %8 2010 %D 2010 %R 10.1002/mrm.22231Journal articles %X High-resolution magic-angle spinning has become a valuable tool to study biologic samples; however, there are only a few high-resolution magic-angle spinning methodologies that have been explored specifically to deal with small semisolid biomaterials such as tissues. Here, we report a novel high-resolution 1H NMR spectroscopic approach using magic-angle coil spinning. We demonstrate its potential for intact tissues by combining a resonant microcoil with a large-volume commercial magic-angle spinning rotor, where the microcoil offers incredible sensitivity and the large-volume magic-angle spinning rotor provides stable slow magic-angle spinning. This approach provides high-resolution spectra with high sensitivity and the preservation of living biologic specimens for an accurate chemical analysis. %G English %L cea-00854518 %U https://cea.hal.science/cea-00854518 %~ CEA %~ CNRS %~ OPENAIRE %~ ERC-CEA %~ PUBNIMBE %~ INC-CNRS %~ IRAMIS-NIMBE %~ IRAMIS %~ GS-PHYSIQUE %~ TEST2-HALCNRS