%0 Journal Article %T A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response %+ Microorganismes et Barrières de l'Hôte (Equipe avenir) %+ Interactions Bactéries-Cellules (UIBC) %+ Laboratoire d'Enzymologie et Biochimie Structurales (LEBS) %+ Institut de biologie structurale (IBS - UMR 5075 ) %+ Centre épigénétique et destin cellulaire (EDC) %+ Instituto de Biologia Molecular e Celular (IBMC) %+ Génopole %+ Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) %A Lebreton, Alice %A Lakisic, Goran %A Job, Viviana %A Fritsch, Lauriane %A Tham, To Nam %A Camejo, Ana %A Matteï, Pierre-Jean %A Regnault, Béatrice %A Nahori, Marie-Anne %A Cabanes, Didier %A Gautreau, Alexis %A Ait-Si-Ali, Slimane %A Dessen, Andréa %A Cossart, Pascale %A Bierne, Hélène %Z LNCC RS10/75-76 Bierne %Z Fundação para a Ciência e a Tecnologia (Portugal) PTDC-SAU/MII/65406/2006 %< avec comité de lecture %@ 0036-8075 %J Science %I American Association for the Advancement of Science (AAAS) %V 331 %N 6022 %P 1319-21 %8 2011-03-11 %D 2011 %R 10.1126/science.1200120 %M 21252314 %K KAP1 %K Immunity %K Listeria-Monocytogenes %K Infection %K Lambda %Z Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM] %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] %Z Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyJournal articles %X Intracellular pathogens such as $Listeria\ monocytogenes$ subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon IFN-stimulated genes (ISGs). IFN-$\lambda$ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with $lntA$-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1$^{+/-}$ mice or when $lntA$ was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-$\lambda$-mediated immune response to control bacterial colonization of the host. %G English %2 https://cea.hal.science/cea-00819299/document %2 https://cea.hal.science/cea-00819299/file/Science_2011_post-print.pdf %L cea-00819299 %U https://cea.hal.science/cea-00819299 %~ PASTEUR %~ CEA %~ CNRS %~ INRA %~ RIIP_PARIS %~ OPENAIRE %~ IBS %~ IBS-PBA %~ AGREENIUM %~ CEA-DRF %~ IRIG %~ CEA-GRE %~ INRAE %~ UP-SCIENCES