First investigation of RH gene polymorphism in patients with sickle cell disease and associated blood donors in Cameroon, Central Africa
Résumé
Although genetic polymorphism of the RH blood group system
is well known in sub-Saharan Africa, national/regional specificities still remain
to be described precisely. For the first time in Cameroon, Central Africa, and in
order to better characterize the molecular basis driving RH phenotype variability,
as well as to identify the main antigens that may be potentially responsible for
alloimmunization, we sought 1) to study the RH genes in a cohort of 109 patients
with sickle cell disease; 2) to study the same genes in the corresponding donors
whose red blood cells (RBCs) were transfused to the patients (108 donors in 98
patients); 3) to predict RH phenotype on the basis of the molecular data and
compare the results with serologic testing; and 4) to identify retrospectively
patients at risk for alloimmunization.
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