TeamProbiHôte, UMR MICALIS

The goals of our team are:

1. To study intestinal and pulmonary microbial ecosystems in order to identify potential beneficial effects on the host as well as their mechanisms of action

2. To explore the immune and physiological responses of the host to bacteria and fungi, commensal and probiotic bacteria in different nutritional contexts

3. To study the host-microbiota crosstalk through diet and supplementation with prebiotics

4. To integrate our work into health issues of physiology (ageing) and physio-pathology (inflammation, colorectal cancer, asthma, metabolic syndrome and obesity) to move towards translational and to propose both complementary prevention and therapy strategies.

Last publications

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  Mélanie Briard, Blanche Guillon, Eric Venot, Marta Grauso, Christelle Hennequet-Antier, et al.. Cytokines and metabolites are the main descriptors of severe asthma in children when performing multi-omics analysis of bronchoaleveolar lavages. 2024. ⟨hal-04678528⟩
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  Mouna Chajadine, Ludivine Laurans, Tobias Radecke, Nirmala Mouttoulingam, Rida Al-Rifai, et al.. Harnessing intestinal tryptophan catabolism to relieve atherosclerosis in mice. Nature Communications, 2024, 15 (1), pp.6390. ⟨10.1038/s41467-024-50807-x⟩. ⟨hal-04670622⟩
• 
  Mathilde Rumeau, Sead Chadi, Frederic Pepke, Martin Beaumont, Laurent Cauquil, et al.. Structure-dependent degradation of milk oligosaccharides by newly isolated intestinal commensal bacterial strains from suckling piglets and rabbits. International Human Microbiome Consortium Congress (IHMC), Jun 2024, Rome, Italy. ⟨hal-04666812⟩
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  Cassandre Bedu-Ferrari, Paul Biscarrat, Frederic Pepke, Sarah Vati, Cyril Chaudemanche, et al.. In-depth characterization of a selection of gut commensal bacteria reveals their functional capacities to metabolize dietary carbohydrates with prebiotic potential. mSystems, 2024, 9 (4), ⟨10.1128/msystems.01401-23⟩. ⟨hal-04663866⟩
• 
  Pierre Lapaquette, Sébastien Terrat, Lil Proukhnitzky, Lucy Martine, Stéphane Grégoire, et al.. Long-term intake of Lactobacillus helveticus enhances bioavailability of omega-3 fatty acids in the mouse retina. npj Biofilms and Microbiomes, 2024, 10 (1), pp.Number 4. ⟨10.1038/s41522-023-00474-5⟩. ⟨hal-04438430⟩

References

Full text

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