Unmanned aerial vehicles (UAVs) play pivotal roles in various applications, from surveillance to delivery services. Efficient path planning for UAVs in dynamic environments with obstacles and moving landing stations is essential to ensure safe and reliable operations. In this study, we propose a novel approach that combines the A* algorithm with the grey wolf optimizer (GWO) for path planning, referred to as GW-A*. Our approach enhances the traditional A algorithm by incorporating weighted nodes, where the weights are determined based on the distance from obstacles and further optimized using GWO. A simulation using dynamic factors such as wind direction and wind speed, which affect the quadrotor UAV in the presence of obstacles, was used to test the new approach, and we compared it with the A* algorithm using various heuristics. The results showed that GW-A* outperformed A* in most scenarios with high and low wind speeds, offering more efficient paths and greater adaptability.