In vivo imaging of the human brain with the Iseult 11.7-T MRI scanner - IRFU
Article Dans Une Revue Nature Methods Année : 2024

In vivo imaging of the human brain with the Iseult 11.7-T MRI scanner

Résumé

The understanding of the human brain is one of the main scientific challenges of the twenty-first century. In the early 2000s, the French Atomic Energy Commission launched a program to conceive and build a human magnetic resonance imaging scanner operating at 11.7 T. We have now acquired human brain images in vivo at such a magnetic field. We deployed parallel transmission tools to mitigate the radiofrequency field inhomogeneity problem and tame the specific absorption rate. The safety of human imaging at such high field strength was demonstrated using physiological, vestibular, behavioral and genotoxicity measurements on the imaged volunteers. Our technology yields T$_2$ and T$_{2*}$ -weighted images reaching mesoscale resolutions within short acquisition times and with a high signal and contrast-to-noise ratio.
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hal-04799579 , version 1 (23-11-2024)

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Nicolas Boulant, Franck Mauconduit, Vincent Gras, Alexis Amadon, Caroline Le Ster, et al.. In vivo imaging of the human brain with the Iseult 11.7-T MRI scanner. Nature Methods, 2024, 21 (11), pp.2013 - 2016. ⟨10.1038/s41592-024-02472-7⟩. ⟨hal-04799579⟩
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