Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective - CRCL-Reprogrammation cellulaire, cellules souches et oncogenèse Access content directly
Journal Articles (Review Article) Trends in Cell Biology Year : 2023

Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective

Abstract

The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticity that may be critical for inducing not only reprogramming and regeneration, but also cancer initiation. Finally, we highlight how a better understanding of the uncoupled control of cellular identity, plasticity, and aging during reprogramming might pave the way to the development of rejuvenating/regenerating strategies in a nontumorigenic manner.
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Dates and versions

hal-04275428 , version 1 (08-11-2023)

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Aurélia Huyghe, Aneta Trajkova, Fabrice Lavial. Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective. Trends in Cell Biology, inPress, ⟨10.1016/j.tcb.2023.07.013⟩. ⟨hal-04275428⟩
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